A New Concept in Relation to Blood Biochemical Parameters with Myocardial Infarction in Bangladeshi Population
Salma Zareen, M Badiuzzaman, SN Uddin, K Choudhury, SK Saha
Background : Blood testing for biochemical markers of Myocardial injury plays an increasingly important
role for the evaluation, diagnosis and triage of patients with chest pain. The guidelines for the diagnosis of
Myocardial Infarction ((MI) have recently changed and prominently incorporate the results of cardiac
marker testing in the clinical definition of MI. We investigated these updated biomarkers and further
compare the differing biology and release kinetics of clinically relevant biomarkers.
Methods: Biochemical changes that occurred in the blood of acute myocardial infarction (AMI) patients
were investigated. Two hundred and fifty two patients, 180 males and 72 females were included in this
study. The mean age was 49.3 ± 9.25 years. Biochemical parameters include serum triglyceride, total
protein, albumin , total bilirubin and total cholesterol to albumin ratio were analyzed.
Results : Biochemical parameters showed that the increased level of triglyceride and total bilirubin were
associated with myocardial infarction. Triglyceride and total bilirubin levels in myocardial infarction
patients were 2.3 ±1.4 mmol/ L and 12.3±3.2 µmol/ L respectively, whereas those of healthy controls were
1.7±1.2 mmol/L for triglycerides and 9.7±3.7 µmol/L for bilirubin. On the other hand, serum total protein
and albumin concentrations were lower in MI patients compared to those of controls. Total protein level
was 65.5 ±3.1 g/L in MI patients and 76.2±5.3 g/L in healthy controls. Albumin levels in both patients and
controls were 40.2 ±3.2 g/L and 45.4 ± 4.5 g/L correspondingly.
Conclusion : Interestingly, serum total cholesterol level was not significantly different in MI patients
compared to controls. In addition, cholesterol/albumin ratio in myocardial infarction patients (0.14 ±
0.04) found to be significantly higher than in healthy controls (0.11± 0.03).